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By Amy Nangia
fUS Imaging Scan
Neuroscientists at Caltech and UCLA have developed a groundbreaking technique called functional ultrasound imaging (fUS) to monitor brain activity in real time. This non-invasive method uses safe, high-frequency sound waves to create remarkably detailed images of the brain. Unlike traditional imaging tools, fUS can capture rapid neural changes deep within the brain without requiring surgery or radiation. It provides a fast and precise way to observe brain function while keeping patients completely safe and comfortable.
fUS works by detecting changes in blood flow in the brain as a person thinks, moves, or feels. Active neurons demand more oxygen, causing blood to flow toward those regions. This allows scientists to pinpoint which parts of the brain are active during specific tasks. fUS is especially valuable because it can access deeper structures like the thalamus and hippocampus-areas that are often difficult to reach using tools like MRI or EEG.
This technology opens up exciting possibilities, particularly for people with neurological disorders. Researchers hope it can help map how the brain behaves in conditions like epilepsy, Alzheimer’s, and depression. It’s even being explored as a way to help people with paralysis communicate, by translating brain signals into digital commands. These early studies suggest that fUS could have a major impact on both diagnosis and treatment.
While we’re still in the early stages, the potential of ultrasound brain reading is massive. Not only is it safer and more affordable than current techniques, but it also brings us closer to truly understanding how our brains work in real time. With further research, this method could completely reshape the future of neuroscience, brain-computer interfaces, and treatments for brain disorders.
fUS Imaging Scan
Sources:
Deffieux, Thomas, et al. “Functional Ultrasound Imaging: A New Imaging Modality for Neuroscience.” Neuroscience, Mar. 2021,
https://doi.org/10.1016/j.neuroscience.2021.03.005. Accessed 16 July 2025. Montaldo, Gabriel, et al. “Functional Ultrasound Neuroimaging.” Annual Review of Neuroscience, vol. 45, no. 1, 8 July 2022, pp. 491–513,
https://doi.org/10.1146/annurev-neuro-111020-100706. Accessed 16 July 2025. “MR Guided Focused Ultrasound.” Uclahealth.org, UCLA Health, 2024, www.uclahealth.org/medical-services/neurosurgery/dbs/treatment-options/mr-guided-foc used-ultrasound. Accessed 16 July 2025.
“SASE Caltech.” Caltech.edu, 2025, sase.caltech.edu/projects/fus.html. Accessed 18 July 2025. “Ultrasound Enables Less-Invasive Brain–Machine Interfaces.” California Institute of Technology, 30 Nov. 2023,
www.caltech.edu/about/news/ultrasound-enables-less-invasive-brainmachine-interfaces. Accessed 16 July 2025.